The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2023
Filed:
Mar. 22, 2021
Applicant:
Biomadison, Inc, Del Mar, CA (US);
Inventors:
Ward C Tucker, Monona, WI (US);
Francis Mark Dunning, Madison, WI (US);
Assignee:
BioMadison, Inc., Del Mar, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); C12Q 1/37 (2006.01); G01N 33/542 (2006.01); C12N 9/52 (2006.01);
U.S. Cl.
CPC ...
C07K 14/00 (2013.01); C12N 9/52 (2013.01); C12Q 1/37 (2013.01); G01N 33/542 (2013.01); G01N 2333/33 (2013.01);
Abstract
Vesicles that incorporate reporting constructs for characterizing Botulinum neurotoxin protease activity and suitable for use in an assay are provided. The reporting constructs are a pair of recombinant hybrid proteins that act in concert. The reporting constructs are a pair of recombinant hybrid proteins that act in concert, and that include a Botulinum neurotoxin protease recognition and cleavage sequence positioned to release a fluorophore upon cleavage.