The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2023
Filed:
Dec. 07, 2016
Applicant:
Pfizer Inc., New York, NY (US);
Inventors:
Durgesh V. Nadkarni, Old Lyme, CT (US);
Jeffry R. Borgmeyer, St. Louis, MO (US);
He Meng, Newton, MA (US);
Qingping Jiang, New Windsor, NY (US);
Assignee:
Pfizer, Inc., New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/18 (2006.01); C07K 1/22 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 1/18 (2013.01); A61K 47/6811 (2017.08); A61K 47/6849 (2017.08);
Abstract
Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.