The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2023

Filed:

Oct. 09, 2020
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Taek Soon Lee, Berkeley, CA (US);

Aram Kang, Richmond, CA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/88 (2006.01); B60K 35/00 (2006.01); C07F 9/09 (2006.01); C12P 5/00 (2006.01); C12N 9/16 (2006.01); C12P 7/04 (2006.01); C12N 9/04 (2006.01); C12N 9/10 (2006.01); C12N 9/12 (2006.01); C08F 136/08 (2006.01); B65G 69/00 (2006.01); G01S 13/931 (2020.01);
U.S. Cl.
CPC ...
B60K 35/00 (2013.01); B65G 69/006 (2013.01); C07F 9/091 (2013.01); C07F 9/098 (2013.01); C08F 136/08 (2013.01); C12N 9/0006 (2013.01); C12N 9/1025 (2013.01); C12N 9/1205 (2013.01); C12N 9/16 (2013.01); C12N 9/88 (2013.01); C12P 5/007 (2013.01); C12P 7/04 (2013.01); C12Y 101/01088 (2013.01); C12Y 203/0301 (2013.01); C12Y 207/01036 (2013.01); C12Y 401/01033 (2013.01); B60K 2370/173 (2019.05); G01S 2013/9314 (2013.01); G01S 2013/9317 (2013.01); G01S 2013/9323 (2020.01); G01S 2013/9324 (2020.01);
Abstract

The present invention provides for a genetically modified host cell capable of producing isopentenol and/or 3-methyl-3-butenol, comprising (a) an increased expression of phosphomevalonate decarboxylase (PMD) (b) an increased expression of a phosphatase capable of converting isopentenol into 3-methyl-3-butenol, (c) optionally the genetically modified host cell does not express, or has a decreased expression of one or more of NudB, phosphomevalonate kinase (PMK), and/or PMD, and (d) optionally one or more further enzymes capable of converting isopentenol and/or 3-methyl-3-butenol into a third compound, such as isoprene.


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