The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2023

Filed:

Jun. 28, 2019
Applicants:

Ohio State Innovation Foundation, Columbus, OH (US);

University of Cincinnati, Cincinnati, OH (US);

Inventors:

Balveen Kaur, Houston, TX (US);

Jeffrey Wojton, Alexandria, VA (US);

Xiaoyang Qi, Cincinnati, OH (US);

Assignees:

University of Cincinnati, Cincinnati, OH (US);

Ohio State Innovation Foundation, Columbus, OH (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/47 (2006.01); A61J 1/00 (2023.01); A61K 31/4188 (2006.01); A61K 31/436 (2006.01); A61K 31/685 (2006.01); A61K 38/17 (2006.01); A61K 45/06 (2006.01); C12N 9/24 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
A61K 38/47 (2013.01); A61J 1/00 (2013.01); A61K 31/4188 (2013.01); A61K 31/436 (2013.01); A61K 31/685 (2013.01); A61K 38/1709 (2013.01); A61K 45/06 (2013.01); C12N 9/2402 (2013.01); A61K 9/0019 (2013.01); A61K 9/1271 (2013.01); A61K 9/1272 (2013.01); A61L 2300/416 (2013.01);
Abstract

The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when administered in conjunction with rampamycin. SapC-DOPS/rapamycin combination therapy allows physicians to give lower doses of each drug and achieve better therapeutic efficacy. The compositions also allow for less toxicity and fewer off-target effects. Related methods and materials are also provided herein.


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