The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2023

Filed:

Aug. 31, 2018
Applicant:

Chronos Therapeutics Limited, Oxford, GB;

Inventors:

Fabrizio Micheli, Verona, IT;

Barbara Bertani, Verona, IT;

Karl Richard Gibson, Kent, GB;

Romano Di Fabio, Verona, IT;

Luca Raveglia, Verona, IT;

Riccardo Zanaletti, Montecchio Maggiore, IT;

Susanna Cremonesi, Verona, IT;

Alfonso Pozzan, Verona, IT;

Teresa Semeraro, Verona, IT;

Luca Tarsi, Verona, IT;

Timothy Jon Luker, Nottinghamshire, GB;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/439 (2006.01); A61K 31/444 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/498 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); C07D 471/08 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/439 (2013.01); A61K 31/444 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/498 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); C07D 471/08 (2013.01); C07D 519/00 (2013.01);
Abstract

There is provided a compound of formula (I), wherein Lto L', Rto R, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, which compounds are useful as antagonists of the orexin-1 and orexin-2 receptors or as selective antagonists of the orexin-1 receptor, and thus, in particular, in the treatment or prevention of inter alia substance dependence, addiction, anxiety disorders, panic disorders, binge eating, compulsive disorders, impulse control disorders, cognitive impairment and Alzheimer's disease.


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