The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2023
Filed:
Feb. 25, 2019
Epicentrx, Inc., La Jolla, CA (US);
Bryan T. Oronsky, Los Altos Hills, CA (US);
Jan Scicinski, Saratoga, CA (US);
Susan Knox, Stanford, CA (US);
William Fitch, Palo Alto, CA (US);
Frans A. Kuypers, El Cerrito, CA (US);
Marcel Fens, San Francisco, CA (US);
Sandra Larkin, Berkeley, CA (US);
Pedro Cabrales, San Diego, CA (US);
Chad Brouse, San Diego, CA (US);
EPICENTRX, INC., La Jolla, CA (US);
Abstract
The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.