The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2023
Filed:
Dec. 30, 2019
Guangdong Provincial Hospital of Tcm, Guangdong, CN;
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, CN;
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong, CN;
Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong, CN;
Bo Liu, Guangdong, CN;
Xianzhang Huang, Guangdong, CN;
Zhimin Yang, Guangdong, CN;
Jun Li, Guangdong, CN;
Quanfu Chen, Guangdong, CN;
Liqiao Han, Guangdong, CN;
Hualun Liang, Guangdong, CN;
Yiqi Yang, Guangdong, CN;
Kai Wang, Guangdong, CN;
Xiaowan Wang, Guangdong, CN;
Ennian Li, Guangdong, CN;
Yi Wang, Guangdong, CN;
Runyue Huang, Guangdong, CN;
Yunshan Wu, Guangdong, CN;
Xiaodong Han, Guangdong, CN;
Jinlang Zhong, Guangdong, CN;
Bidan Zheng, Guangdong, CN;
Guangdong Provincial Hospital of TCM, Guangdong, CN;
The Second Affiliated Hospital Of Guangzhou University of Chinese Medicine, Guangdong, CN;
The Second Clinical College Of Guangzhou University of Chinese Medicine, Guangdong, CN;
Guangdong Provincial Academy Of Chinese Medical Sciences, Guangdong, CN;
Abstract
Disclosed in the present invention is a new triptolide derivative as shown in formula (I). Also disclosed in the present invention are a preparation method for the compound and the medical use thereof in preparation of anti-cancer drugs. Triptolide acrylate of the present invention and a pharmaceutically acceptable salt thereof have anti-cancer activity, and after animal in-vivo experiments, can effectively inhibit tumor growth in animals. A plurality of in-vitro experiments proves that same can significantly increase the protein expression quantity of p53, promote the apoptosis of tumor cells, effectively inhibit the growth of the tumor cells, and have the effect of inhibiting metastasis of cancer cells. More importantly, the toxicity of the compound to normal cells is less than that of triptolide.