The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2023
Filed:
Jan. 14, 2015
Rush University Medical Center, Chicago, IL (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Anna Plaas, Chicago, IL (US);
Vincent Wang, Naperville, IL (US);
John Sandy, Chicago, IL (US);
Rebecca Bell, New York, NY (US);
Jorge Galante, Sanibel, FL (US);
Katie J. Trella, Chicago, IL (US);
Rush University Medical Center, Chicago, IL (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Abstract
A method for monitoring a treatment of a subject having a musculoskeletal disorder is provided. The method includes measuring a first expression level of at least two biomarkers at a treatment site prior to the treatment and measuring a second expression level of the at least two biomarkers at the treatment site after the treatment begins. The method further includes comparing the first expression level of the at least two biomarkers prior to the treatment to the second expression level of the at least two biomarkers post treatment and continuing the treatment, altering the treatment or stopping the treatment based on the comparison. A method of treating a musculoskeletal disorder in a subject is also provided. The method includes removing a aggrecan-hyaluronan matrix from a treatment site in the subject.