The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2023
Filed:
May. 04, 2020
Applicant:
Iridia, Inc., Carlsbad, CA (US);
Inventors:
Paul F. Predki, Carlsbad, CA (US);
Stefen Boehme, Encinitas, CA (US);
Assignee:
IRIDIA, INC., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/90 (2006.01); B01L 3/00 (2006.01); C12N 15/74 (2006.01); C12P 19/34 (2006.01);
U.S. Cl.
CPC ...
C12N 9/90 (2013.01); B01L 3/508 (2013.01); C12N 15/74 (2013.01); C12P 19/34 (2013.01); C12Y 599/01002 (2013.01); B01L 2300/047 (2013.01);
Abstract
The disclosure provides novel topoisomerases which exhibit weakened ability to form a covalent bond to the 5'-(C/T)CCTT-3′ recognition site in the presence of increased NaCl concentrations relative to wild-type, together with novel methods for synthesizing DNA in the 3′ to 5′ direction using the novel topoisomerase; and other compounds, compositions, methods and devices comprising or utilizing topoisomerases which exhibit reduced covalent bond formation to the 5′-(C/T)CCTT-3′ recognition site in the presence of increased NaCl concentrations, relative to wild-type.