The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2023
Filed:
Jan. 03, 2019
Sichuan Kelun-biotech Biopharmaceutical Co., Ltd., Sichuan, CN;
Tongtong Xue, Sichuan, CN;
Qiang Li, Shanghai, CN;
Liang Xiao, Sichuan, CN;
Yuncheng Zheng, Shanghai, CN;
Dengnian Liu, Sichuan, CN;
Si Chen, Shanghai, CN;
Yan Hu, Sichuan, CN;
Lichun Wang, Sichuan, CN;
Jingyi Wang, Sichuan, CN;
SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD., Sichuan, CN;
Abstract
The present invention relates to the field of treatment of diseases and immunology. Specifically, the present invention relates to an anti-LAG-3 antibody or an antigen-binding fragment thereof, nucleic acid molecules for encoding said antibody and fragment, and method for preparing said antibody and fragment. The anti-LAG-3 antibody or the antigen-binding fragment thereof according to the present invention has high specificity and high affinity to LAG-3, can effectively block the binding of LAG-3 to MHC II and/or FGL1, and can inhibit and/or block intracellular signaling mediated by LAG-3 binding to MHC II and/or FGL1. Therefore, the present invention further relates to a pharmaceutical composition comprising the antibody or the antigen-binding fragment thereof, and use of the pharmaceutical composition in the preparation of drugs. The drugs are used for improving the activity of immune cells and enhancing the immune response, or are used for preventing and/or treating tumors, infections or autoimmune diseases.