The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2023
Filed:
Oct. 17, 2022
Sph No.1 Biochemical & Pharmaceutical Co.,ltd., Shanghai, CN;
Shanghai Jiaotong University, Shanghai, CN;
Wanbin Zhang, Shanghai, CN;
Mo Wang, Shanghai, CN;
Lu Zhang, Shanghai, CN;
Xiaohong Huo, Shanghai, CN;
Zhenfeng Zhang, Shanghai, CN;
Qianjia Yuan, Shanghai, CN;
Jianzhong Chen, Shanghai, CN;
SPH NO.1 BIOCHEMICAL & PHARMACEUTICAL CO., LTD., Shanghai, CN;
Shanghai Jiaotong University, Shanghai, CN;
Abstract
A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir. Specifically, a nucleoside and phosphoryl chloride are subjected to asymmetric reaction under the catalysis of a chiral bicyclic imidazole catalyst in the presence of a base to produce the P-stereogenic nucleoside derivative of formula (3)