The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2023
Filed:
Jul. 17, 2020
Shanghai Institute of Material Medica, Chinese Academy of Sciences, Shanghai, CN;
Bing Xiong, Shanghai, CN;
Jia Li, Shanghai, CN;
Meiyu Geng, Shanghai, CN;
Jingkang Shen, Shanghai, CN;
Yi Zang, Shanghai, CN;
Jing Ai, Shanghai, CN;
Danqi Chen, Shanghai, CN;
Qi Wang, Shanghai, CN;
Ying Dong, Shanghai, CN;
Xia Peng, Shanghai, CN;
Yinchun Ji, Shanghai, CN;
Qian Tan, Shanghai, CN;
Abstract
The present disclosure relates to a fused ring pyrimidine amino compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically disclosed in the present disclosure are the compound shown in formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof. The fused ring pyrimidine amino compound of the present application has good inhibitory activity against DDRs, particularly DDR2, and has a good therapeutic effect on tumors and fibrotic diseases, especially pulmonary inflammation and pulmonary fibrosis. Also disclosed in the present disclosure are a preparation method for the compound shown in formula I, and a use thereof.