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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11650277 B1

PDFFull Text
Date of Patent:
May. 16, 2023

Filed:

Apr. 09, 2019

Ttfield treatment with optimization of electrode positions based on low frequency (<1mhz) ac conductivity estimates derived from two mri images having different repetition times

Applicant:

Novocure Limited, St. Helier, JE;

Inventors:

Cornelia Wenger, Ericeira, PT;

Catherine Tempel-Brami, Matan, IL;

Hadas Sara Hershkovich, Kiryat Motzkin, IL;

Moshe Giladi, Moshav Herut, IL;

Zeev Bomzon, Kiryat Tivon, IL;

Assignee:

Novocure GmbH, Root, CH;

Attorney:

Potomac Law Group, PLLC

Primary Examiner:

Keith M Raymond

Assistant Examiner:

Sean A Frith

Int. Cl.
CPC ...
G01R 33/56 (2006.01); A61N 1/36 (2006.01); A61B 5/00 (2006.01); A61N 1/04 (2006.01); A61B 5/055 (2006.01); A61B 5/053 (2021.01); G01R 33/48 (2006.01); A61N 1/00 (2006.01); G01R 33/58 (2006.01);
U.S. Cl.
CPC ...
G01R 33/56 (2013.01); A61B 5/0042 (2013.01); A61B 5/053 (2013.01); A61B 5/055 (2013.01); A61N 1/00 (2013.01); A61N 1/0476 (2013.01); A61N 1/36002 (2017.08); G01R 33/4808 (2013.01); G01R 33/5602 (2013.01); G01R 33/5607 (2013.01); G01R 33/5608 (2013.01); A61B 2576/026 (2013.01); G01R 33/58 (2013.01);
Abstract

A 3D model of AC electrical conductivity (at a given frequency) of an anatomic volume can be created by obtaining two MRI images of the anatomic volume, where the two images have different repetition times. Then, for each voxel in the anatomic volume, a ratio IR of the intensity of the corresponding voxels in the two MRI images is calculated. This calculated IR is then mapped into a corresponding voxel of a 3D model of AC electrical conductivity at the given frequency. The given frequency is below 1 MHz (e.g., 200 kHz). In some embodiments, the 3D model of AC electrical conductivity at the given frequency is used to determine the positions for the electrodes in TTFields (Tumor Treating Fields) treatment.

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