The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2023
Filed:
May. 14, 2019
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
George M. Church, Brookline, MA (US);
Kevin M. Esvelt, Auburndale, MA (US);
Prashant G. Mali, La Jolla, CA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 15/90 (2006.01); C12N 15/85 (2006.01); C12N 9/22 (2006.01); C12N 15/113 (2010.01); C07K 2/00 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/907 (2013.01); C07K 2/00 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/113 (2013.01); C12N 15/85 (2013.01); C12N 2310/3519 (2013.01); C12N 2320/33 (2013.01); C12N 2320/50 (2013.01); C12N 2800/107 (2013.01); C12N 2800/40 (2013.01); C12N 2800/80 (2013.01); C12N 2810/10 (2013.01); C12N 2830/00 (2013.01); C12N 2830/34 (2013.01); C12N 2999/007 (2013.01); C12Y 301/00 (2013.01);
Abstract
Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.