The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2023
Filed:
Jun. 29, 2018
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Aditya Mohan Kunjapur, Cambridge, MA (US);
George M. Church, Brookline, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12N 9/52 (2006.01); C12N 9/00 (2006.01); C12N 15/74 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1058 (2013.01); C12N 9/52 (2013.01); C12N 9/93 (2013.01); C12N 15/74 (2013.01); C12N 15/90 (2013.01); C12Y 601/01 (2013.01);
Abstract
The disclosure provides methods of making a protein having a desired non-standard amino acid incorporated at its N-terminus in a cell and methods of screening for an amino acyl tRNA synthetase variant that preferentially selects a non-standard amino acid against its standard amino acid counterpart or undesired non-standard amino acids for incorporation into a protein in a cell.