The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2023
Filed:
May. 24, 2017
Applicant:
Insmed Incorporated, Bridgewater, NJ (US);
Inventors:
Karl Edwin Griswold, Lyme, NH (US);
Chris Bailey-Kellogg, Strafford, VT (US);
Yoonjoo Choi, Gyeonggi-do, KR;
Assignee:
Insmed Incorporated, Bridgewater, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); A61K 45/06 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01);
Abstract
Provided are variants of a chimeric anti-EGFR antibody. In various embodiments, the variants exhibit substantially improved thermostabilities and/or substantially higher levels of humanness, while retaining binding affinity near the parental level. The consistently high quality of the turnkey CoDAH designs, over a whole panel of variants, suggests that a computationally-directed approach encapsulates key determinants of antibody structure and function.