The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 16, 2023

Filed:

Jun. 22, 2018
Applicants:

Systimmune, Inc., Redmond, WA (US);

Sichuan Baili Pharmaceutical Co. Ltd., Chengdu, CN;

Inventors:

Yi Zhu, Chengdu, CN;

Ole Olsen, Everett, WA (US);

Dong Xia, Redmond, WA (US);

David Jellyman, Duvall, WA (US);

Katrina Bykova, Seattle, WA (US);

Anne-Marie K. Rousseau, Seattle, WA (US);

Bill Brady, Bothell, WA (US);

Blair Renshaw, Renton, WA (US);

Brian Kovacevich, Snohomish, WA (US);

Yu Liang, Redmond, WA (US);

Zeren Gao, Redmond, WA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61K 47/68 (2017.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 47/6803 (2017.08); C07K 16/2809 (2013.01); C07K 16/2827 (2013.01); C07K 16/2863 (2013.01); C07K 2317/31 (2013.01); C07K 2317/55 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01);
Abstract

The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen.


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