The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 16, 2023

Filed:

May. 06, 2016
Applicant:

Laboratoire Francais Du Fractionnement ET Des Biotechnologies, Les Ulis, FR;

Inventors:

Celine Monnet, Lambersart, FR;

Philippe Mondon, Neuve Chapelle, FR;

Alexandre Fontayne, La Madeleine, FR;

Christophe De Romeuf, Lambersart, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/735 (2006.01); C07K 16/28 (2006.01); C07K 16/00 (2006.01); A61K 39/395 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70535 (2013.01); A61K 39/395 (2013.01); C07K 16/00 (2013.01); C07K 16/2803 (2013.01); C07K 16/2887 (2013.01); G01N 33/53 (2013.01); G01N 33/6857 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/41 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/53 (2013.01); C07K 2317/71 (2013.01); C07K 2317/72 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2319/30 (2013.01);
Abstract

Disclosed is to a polypeptide including a mutated Fc region and having functional activity, mediated by the Fc region, that is modified compared with that of a parent polypeptide. The Fc region includes at least one combination of 2 mutations, the combination being selected from among one mutation selected from among a first set of mutations, and at least one mutation selected from among a second set of mutations, and provided that mutation (i) does not take place on the same amino acid as mutation (ii). Also disclosed are use of the polypeptide, compositions including the same, and methods for preparing the polypeptide.


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