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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11649268 B1

PDFFull Text
Date of Patent:
May. 16, 2023

Filed:

Jun. 14, 2017

Fibronectin-binding peptides for use in tumor or fibrosis diagnosis and therapy

Applicants:

Eth Zurich, Zurich, CH;

Paul Scherrer Institut, Villigen, CH;

Inventors:

Mamta Chabria, Zurich, CH;

Alessandra Moscaroli, Zurich, CH;

Simon Arnoldini, Zurich, CH;

Samuel Hertig, San Francisco, CA (US);

Viola Vogel, Baden, CH;

Martin Behe, Gelterkinden, CH;

Roger Schibli, Baden, CH;

Assignees:

ETH ZURICH, Zurich, CH;

PAUL SCHERRER INSTITUT, Villigen PSI, CH;

Attorneys:

Bryan D. Zerhusen

Nicholas R. Herrel

Cantor Colburn LLP

Primary Examiner:

Gary B Nickol

Assistant Examiner:

Lakia J Jackson-Tongue

Int. Cl.
CPC ...
C07K 14/435 (2006.01); A61K 47/64 (2017.01); A61K 47/54 (2017.01); A61K 49/00 (2006.01); A61K 49/14 (2006.01); A61K 49/22 (2006.01); A61K 51/04 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/435 (2013.01); A61K 47/549 (2017.08); A61K 47/64 (2017.08); A61K 49/0056 (2013.01); A61K 49/14 (2013.01); A61K 49/221 (2013.01); A61K 51/0497 (2013.01); A61K 38/00 (2013.01);
Abstract

The present invention is directed to a composition comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic agent, a nucleic acid encoding a fusion polypeptide comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic polypeptide agent as well as a corresponding recombinant vector and host cell comprising such a nucleic acid and preferably expressing said fusion polypeptide. The invention also relates to a kit of parts comprising at least one fibronectin binding polypeptide (FnBP), at least one diagnostic or therapeutic agent, and optionally one or more chemical agents for linking the fibronectin binding polypeptide (FnBP) to the diagnostic or therapeutic agent. In addition, the present invention intends said composition, nucleic acid, vector, host cell and kit for use in the therapeutic or prophylactic treatment of a disease, preferably a disease associated with abnormal fibronectin accumulation such as cancer, fibrosis or immune diseases.

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