The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2023
Filed:
Jun. 16, 2022
Hongene Biotech Corporation, Union City, CA (US);
Xiaoyang Guan, Fremont, CA (US);
David Yu, Union City, CA (US);
Ruiming Zou, Union City, CA (US);
Xiaoling Zheng, Union City, CA (US);
John Liu, Union City, CA (US);
Aldrich N. K. Lau, Palo Alto, CA (US);
Wing C. Poon, Union City, CA (US);
Gang Zhao, Union City, CA (US);
Gengyu Du, Union City, CA (US);
Yun-Chiao Yao, Union City, CA (US);
Hongene Biotech Corporation, Union City, CA (US);
Abstract
Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.