IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11649229 B1

PDFFull Text
Date of Patent:
May. 16, 2023

Filed:

Dec. 28, 2020

Amide compounds for treatment of immune and inflammatory disorders

Applicant:

Achillion Pharmaceuticals, Inc., Boston, MA (US);

Inventors:

Jason Allan Wiles, Madison, CT (US);

Avinash S. Phadke, Branford, CT (US);

Milind Deshpande, Madison, CT (US);

Atul Agarwal, Hamden, CT (US);

Dawei Chen, Guilford, CT (US);

Venkat Rao Gadhachanda, Hamden, CT (US);

Akihiro Hashimoto, Branford, CT (US);

Godwin Pais, Hamden, CT (US);

Qiuping Wang, Bethany, CT (US);

Xiangzhu Wang, Branford, CT (US);

William Greenlee, Teaneck, NJ (US);

Assignee:

Achillion Pharmaceuticals, Inc., Boston, MA (US);

Attorney:

Clark & Elbing LLP

Primary Examiner:

Brenda L Coleman

Int. Cl.
CPC ...
A61K 31/416 (2006.01); A61K 31/437 (2006.01); A61K 31/5025 (2006.01); C07D 231/56 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); A61P 1/00 (2006.01); A61P 1/16 (2006.01); A61P 27/02 (2006.01); C07D 413/14 (2006.01); C07D 403/14 (2006.01); C07D 401/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 513/04 (2006.01); C07F 9/6558 (2006.01);
U.S. Cl.
CPC ...
C07D 413/14 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 513/04 (2013.01); C07F 9/65583 (2013.01);
Abstract

Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I'″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

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