The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2023
Filed:
Dec. 20, 2019
Applicant:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Inventors:
Samuel Strober, Stanford, CA (US);
Robert Lowsky, Stanford, CA (US);
Assignee:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/12 (2015.01); A61K 35/28 (2015.01); A61K 35/22 (2015.01); A61K 35/14 (2015.01); A61K 38/19 (2006.01); A61K 41/00 (2020.01); A61K 45/06 (2006.01); A61K 31/365 (2006.01); A61K 31/436 (2006.01); A61K 31/573 (2006.01); A61K 38/13 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61N 5/10 (2006.01); A61K 35/17 (2015.01);
U.S. Cl.
CPC ...
A61K 35/12 (2013.01); A61K 31/365 (2013.01); A61K 31/436 (2013.01); A61K 31/573 (2013.01); A61K 35/14 (2013.01); A61K 35/17 (2013.01); A61K 35/22 (2013.01); A61K 35/28 (2013.01); A61K 38/13 (2013.01); A61K 38/193 (2013.01); A61K 39/001 (2013.01); A61K 39/39541 (2013.01); A61K 41/00 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); A61K 39/395 (2013.01); A61K 2035/122 (2013.01); A61K 2035/124 (2013.01); A61K 2039/515 (2013.01); A61K 2039/54 (2013.01); A61K 2039/57 (2013.01);
Abstract
Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to an HLA mismatched recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.