IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11648243 B1

PDFFull Text
Date of Patent:
May. 16, 2023

Filed:

Dec. 01, 2020

Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors

Applicant:

Array Biopharma Inc., Boulder, CO (US);

Inventors:

Steven W. Andrews, Boulder, CO (US);

Sean Aronow, Boulder, CO (US);

James F. Blake, Boulder, CO (US);

Barbara J. Brandhuber, Boulder, CO (US);

James Collier, Boulder, CO (US);

Adam Cook, Boulder, CO (US);

Julia Haas, Boulder, CO (US);

Yutong Jiang, Boulder, CO (US);

Gabrielle R. Kolakowski, Boulder, CO (US);

Elizabeth A. Mcfaddin, Boulder, CO (US);

Megan L. Mckenney, Boulder, CO (US);

Oren T. McNulty, Boulder, CO (US);

Andrew T. Metcalf, Boulder, CO (US);

David A. Moreno, Boulder, CO (US);

Ginelle A. Ramann, Boulder, CO (US);

Tony P. Tang, Boulder, CO (US);

Li Ren, Boulder, CO (US);

Shane M. Walls, Boulder, CO (US);

Assignee:

Array Biopharma Inc., Boulder, CO (US);

Attorney:

Bradley W. Crawford

Primary Examiner:

Brian J Davis

Int. Cl.
CPC ...
A61K 31/4545 (2006.01); A61K 31/4162 (2006.01); C07D 471/04 (2006.01); A61P 1/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61K 31/444 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); A61P 1/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4545 (2013.01); A61K 31/4162 (2013.01); A61K 31/444 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61P 1/00 (2018.01); A61P 1/12 (2018.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07D 471/04 (2013.01);
Abstract

Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X, X, X, X, Ring D, E, R, R, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Find Patent Forward Citations

Loading…