The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 16, 2023

Filed:

Nov. 05, 2019
Applicant:

Grape King Bio Ltd., Taoyuan, TW;

Inventors:

Pei-Shan Liu, Taipei, TW;

Chien-Chih Chen, Taipei, TW;

Chin-Chu Chen, Taoyuan, TW;

Li-Ya Lee, Taoyuan, TW;

Wan-Ping Chen, Taoyuan, TW;

Ting-Wei Lin, Taoyuan, TW;

Jui-Hsia Hsu, Taoyuan, TW;

Wei-Ching Chu, Taoyuan, TW;

Assignee:

GRAPE KING BIO LTD., Taoyuan, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/343 (2006.01); C07D 493/06 (2006.01); C12N 1/14 (2006.01); A61K 9/14 (2006.01); A61K 36/07 (2006.01); C12P 17/18 (2006.01); C12R 1/645 (2006.01);
U.S. Cl.
CPC ...
A61K 31/343 (2013.01); A61K 9/14 (2013.01); A61K 36/07 (2013.01); C07D 493/06 (2013.01); C12N 1/145 (2021.05); C12P 17/181 (2013.01); A61K 2236/11 (2013.01); A61K 2236/33 (2013.01); A61K 2236/331 (2013.01); A61K 2236/53 (2013.01); C12R 2001/645 (2021.05);
Abstract

The present invention is related to an active substance ofhaving a pain-relieving effect, and a pharmaceutical composition including the active substance. The active substance is prepared using the following steps: (a) inoculating a mycelium ofon an agar plate and incubating at 15-32° C. for 8-16 days; (b) inoculating the incubatedmycelia from step (a) into a medium in a flask and incubating at 20-30° C. and pH 4.5-6.5 for 3-5 days; (c) inoculating the incubatedmycelia from step (b) into a medium in a fermentation tank and incubating at 24-32° C. and pH 4.5-5.5 for 8-16 days to obtain a fermented medium of themycelia; and (d) desiccating the fermented medium of themycelia from step (c) to obtain the powder of themycelia, which is further purified and isolated to obtain a novel compound of


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