The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2023
Filed:
Dec. 29, 2020
Applicants:
Io Therapeutics, Inc., Houston, TX (US);
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Gabriel Ghiaur, Baltimore, MD (US);
Richard J. Jones, Baltimore, MD (US);
Salvador Alonso, Baltimore, MD (US);
Roshantha A. Chandraratna, San Juan Capistrano, CA (US);
Assignees:
IO Therapeutics, Inc., Spring, TX (US);
The Johns Hopkins Univercity, Baltimore, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/196 (2006.01); A61K 45/06 (2006.01); A61K 31/192 (2006.01); A61K 31/4166 (2006.01); A61K 31/454 (2006.01); A61K 31/4196 (2006.01); A61K 31/138 (2006.01); A61K 31/58 (2006.01); A61K 31/4545 (2006.01); A61K 31/5685 (2006.01); A61K 31/277 (2006.01); A61P 35/00 (2006.01); A61K 31/69 (2006.01);
U.S. Cl.
CPC ...
A61K 31/196 (2013.01); A61K 31/138 (2013.01); A61K 31/192 (2013.01); A61K 31/277 (2013.01); A61K 31/4166 (2013.01); A61K 31/4196 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/5685 (2013.01); A61K 31/58 (2013.01); A61K 31/69 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01);
Abstract
Disclosed herein are methods for treating a cancer comprising administering to a subject in need thereof an effective dose of a CYP26-resistant retinoic acid receptor (RAR) alpha (RARα) selective agonist, whereby as a result of the treatment the tumor burden is reduced in the subject and cancer stem cells resident in the bone marrow are substantially reduced.