The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2023
Filed:
Nov. 30, 2017
Applicant:
Yale University, New Haven, CT (US);
Inventors:
David L. Rimm, Branford, CT (US);
Kurt Schalper, Branford, CT (US);
Assignee:
YALE UNIVERSITY, New Haven, CT (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57423 (2013.01); C07K 16/2818 (2013.01); G01N 2333/4739 (2013.01); G01N 2333/7051 (2013.01); G01N 2333/70514 (2013.01); G01N 2333/70517 (2013.01); G01N 2333/70589 (2013.01); G01N 2333/96436 (2013.01); G01N 2800/52 (2013.01);
Abstract
The present disclosure provides a method of treating cancer by immune checkpoint blockade, or selecting patients for treatment with immune checkpoint blockers, by detecting tumors with high levels of T-lymphocytes with low levels of activation and proliferation. In various embodiments the tissue sample may be from a conventional biopsy. In various embodiments the cancer may be non-small cell lung cancer.