The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 09, 2023

Filed:

Apr. 29, 2022
Applicant:

Bayer Pharma Aktiengesellschaft, Berlin, DE;

Inventors:

Hans-Georg Lerchen, Leverkusen, DE;

Anne-Sophie Rebstock, Champagne au Mont d'Or, FR;

Yolanda Cancho Grande, Leverkusen, DE;

Sven Wittrock, Berlin, DE;

Beatrix Stelte-Ludwig, Wülfrath, DE;

Dennis Kirchhoff, Berlin, DE;

Christoph Mahlert, Wuppertal, DE;

Simone Greven, Dormagen, DE;

Stephan Märsch, Cologne, DE;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/28 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 31/40 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2866 (2013.01); A61K 31/40 (2013.01); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); A61P 35/00 (2018.01);
Abstract

The invention relates to specific Antibody-Drug-Conjugates (ADCs) with KSP inhibitors and anti-CD123-antibodies, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.


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