The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2023
Filed:
Feb. 10, 2019
Applicant:
Bioasis Technologies, Inc., Gulford, CT (US);
Inventors:
Timothy Z. Vitalis, Vancouver, CA;
Reinhard Gabathuler, Montreal, CA;
Assignee:
BIOASIS TECHNOLOGIES, INC., Richmond, CA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 14/79 (2006.01); C07K 16/32 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
C07K 14/79 (2013.01); A61K 39/39558 (2013.01); C07K 16/32 (2013.01); A61K 2039/505 (2013.01); C07K 2317/515 (2013.01); C07K 2317/732 (2013.01); C07K 2319/10 (2013.01); C07K 2319/74 (2013.01);
Abstract
Provided are p97 (melanotransferrin)-trastuzumab fusion proteins and related methods of use thereof, for instance, to facilitate delivery of trastuzumab across the blood-brain barrier (BBB) and/or improve tissue penetration of the antibody in CNS and peripheral tissues, and thereby treat and/or diagnose HER2-positive cancers, including those of the central nervous system (CNS).