The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2023
Filed:
Mar. 17, 2022
Applicant:
Denali Therapeutics Inc., South San Francisco, CA (US);
Inventors:
Gerald Maxwell Cherf, South San Francisco, CA (US);
Gunasekaran Kannan, South San Francisco, CA (US);
Katrina W. Lexa, South San Francisco, CA (US);
Ray L. Y. Low, South San Francisco, CA (US);
Rachel Prorok, South San Francisco, CA (US);
Ankita Srivastava, South San Francisco, CA (US);
Assignee:
Denali Therapeutics Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61P 25/28 (2006.01); C07K 14/475 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/47 (2013.01); A61P 25/28 (2018.01); C07K 14/475 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.