The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2023
Filed:
Jun. 05, 2020
Applicant:
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Inventors:
Ernst Schönbrunn, Tampa, FL (US);
Nicholas J. Lawrence, Tampa, FL (US);
Harshani R. Lawrence, Tampa, FL (US);
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., Tampa, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/48 (2006.01); C07D 491/048 (2006.01); C07D 405/14 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 403/14 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 239/48 (2013.01); A61P 35/00 (2018.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 491/048 (2013.01); A61K 45/06 (2013.01);
Abstract
Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.