The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2023
Filed:
Sep. 13, 2018
Applicant:
Nanomab Technology Limited, Hong Kong, CN;
Inventors:
Hong Hoi Ting, Shanghai, CN;
Chung Lim Wong, Shanghai, CN;
Assignee:
NANOMAB TECHNOLOGY LIMITED, Hong Kong, HK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61K 49/16 (2006.01); A61K 51/08 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6849 (2017.08); A61K 47/6803 (2017.08); A61K 49/16 (2013.01); A61K 51/088 (2013.01); G01N 33/6872 (2013.01);
Abstract
Disclosed is the use of a radiolabeled anti-nanobody in the prognosis and diagnosis of cancers. In particular, disclosed is an immunoconjugate for detecting a PD-L1 molecule. The immunoconjugate comprises the VHH chain of a specific anti-PD-L1 nanobody and a radionuclide, and can be used for non-invasive detecting of expression of the object PD-L1 to be detected. The immunoconjugate of the invention has small size and high specificity, and is suitable for systemic detection which simultaneously targets primary and metastatic tumors, and has high accuracy and low radiation dose.