The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2023
Filed:
Jul. 22, 2022
Applicant:
Krystal Biotech, Inc., Pittsburgh, PA (US);
Inventors:
Pooja Agarwal, Mars, PA (US);
Suma Krishnan, Pittsburgh, PA (US);
John C. Freedman, Pittsburgh, PA (US);
Assignee:
Krystal Biotech, Inc., Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/763 (2015.01); A61K 38/17 (2006.01); A61K 38/39 (2006.01); A61K 48/00 (2006.01); A61K 9/00 (2006.01); A61P 17/02 (2006.01); A61P 17/04 (2006.01); C12N 5/071 (2010.01); C12N 9/02 (2006.01); A61K 38/57 (2006.01); A61P 17/00 (2006.01); C12N 15/52 (2006.01); C12N 15/86 (2006.01); A61K 9/06 (2006.01); A61K 47/38 (2006.01);
U.S. Cl.
CPC ...
A61K 35/763 (2013.01); A61K 9/0014 (2013.01); A61K 38/1748 (2013.01); A61K 38/39 (2013.01); A61K 38/57 (2013.01); A61K 48/005 (2013.01); A61P 17/00 (2018.01); A61P 17/02 (2018.01); A61P 17/04 (2018.01); C12N 5/0629 (2013.01); C12N 9/0071 (2013.01); C12N 15/52 (2013.01); C12N 15/86 (2013.01); A61K 9/06 (2013.01); A61K 47/38 (2013.01); C12N 2710/16643 (2013.01); C12Y 114/11004 (2013.01);
Abstract
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a Serine Protease Inhibitor Kazal-type (SPINK) polypeptide (e.g., a SPINK5 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of Netherton Syndrome); and articles of manufacture or kits thereof.