The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2023
Filed:
Sep. 28, 2018
Novartis Ag, Basel, CH;
Elodia Di Renzo, Basel, CH;
David Hook, Rheinfelden, CH;
Markus Krumme, Allschwil, CH;
Steffen Lang, Reinach, CH;
Massimo Moratto, Basel, CH;
Joerg Ogorka, Reinach, CH;
Jim Parks, Belmont, CA (US);
Dale Ploeger, Menlo Park, CA (US);
Norbert Rasenack, Weil am Rhein, DE;
Hendrik Schneider, Basel, CH;
Stefan Steigmiller, Freiburg, DE;
Gordon Stout, El Cerrito, CA (US);
Patrick Tritschler, Freiburg, DE;
Fabian Weber, Freiburg, DE;
Novartis AG, Basel, CH;
Abstract
A method of preparing a pharmaceutical product comprises the steps of (a) providing a neat active pharmaceutical ingredient (API) complying with at least five of the following parameters determined by using a FT4 powder rheometer: (i) specific basic flow energy of at most 60 mJ/g; (ii) stability index of 0.75 to 1.25; (iii) specific energy of at most 10 mJ/g; (iv) major principle stress at 15 kPa of at most 40; (v) flow function at 15 kPa of at least 1.3; (vi) consolidated bulk density at 15 kPa of at least 0.26 g/mL; (vii) compressibility of at most 47%; and (viii) wall friction angle of at most 40°; (b) dispensing the neat API of step (a) into a bottom part of a pharmaceutical carrier using a vacuum assisted metering and filling device; and (c) encapsulating the bottom part, thereby producing a pharmaceutical product.