The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 02, 2023

Filed:

Jul. 20, 2022
Applicant:

Corning Incorporated, Corning, NY (US);

Inventors:

Ann MeeJin Ferrie, Salem, NH (US);

Vasiliy Nikolaevich Goral, Painted Post, NY (US);

Assignee:

CORNING INCORPORATED, Corning, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/12 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); C12M 3/00 (2006.01); C12N 5/00 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12M 25/14 (2013.01); C12M 23/02 (2013.01); C12M 23/20 (2013.01); C12M 23/44 (2013.01); C12M 25/04 (2013.01); C12M 29/10 (2013.01); C12M 29/26 (2013.01); C12M 41/26 (2013.01); C12M 25/02 (2013.01); C12N 5/0068 (2013.01); C12N 5/0602 (2013.01); C12N 2513/00 (2013.01); C12N 2533/30 (2013.01); C12N 2533/40 (2013.01); C12N 2533/90 (2013.01); C12N 2535/00 (2013.01);
Abstract

A packed-bed bioreactor system is provided, the system including a cell culture vessel having a first end, a second end, and a reservoir between the first and second ends; and a cell culture matrix disposed in the reservoir. The cell culture matrix includes a structurally defined substrate with a plurality of interwoven fibers having surfaces for adhering cells thereto. The substrate is disposed within the reservoir in a wound configuration creating a plurality of layers of substrate in the wound configuration, and none of the plurality of layers of substrate are separated by a spacer material.


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