The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2023
Filed:
May. 05, 2014
Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
Applicant:
Roche Glycart Ag, Schlieren, CH;
Inventors:
Peter Bruenker, Hittnau, CH;
Tanja Fauti, Zurich, CH;
Christiane Neumann, Wallisellen, CH;
Christian Klein, Bonstetten, CH;
Pablo Umana, Wollerau, CH;
Assignee:
Roche Glycart AG, Schlieren, CH;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); C07K 16/3053 (2013.01); C07K 16/2809 (2013.01); C07K 16/30 (2013.01); C07K 2317/31 (2013.01); C07K 2317/52 (2013.01); C07K 2317/55 (2013.01); C07K 2317/66 (2013.01);
Abstract
The present invention relates to bispecific antibodies that specifically bind a T-cell activating antigen and a Tumor Antigen (TA), comprising a first Fab fragment and a second Fab fragment, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody does not comprise a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.