The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2023
Filed:
Mar. 06, 2019
Applicant:
Amgen (Europe) Gmbh, Risch-Rotkreuz, CH;
Inventor:
William R. Baker, Bellevue, WA (US);
Assignees:
AMGEN (EUROPE) GMBH, Risch-Rotkreuz, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 209/48 (2006.01); A61P 1/04 (2006.01); C07C 245/06 (2006.01); C07D 401/04 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07D 209/48 (2013.01); A61K 9/0053 (2013.01); A61P 1/04 (2018.01); C07C 245/06 (2013.01); C07D 401/04 (2013.01);
Abstract
Provided herein are azo prodrugs of small-molecule isoindoline-1,3-diones and isoindoles anti-inflammatory inhibitors according to formula IA, in particular PDE4 inhibitors, which prodrugs can be administered orally to a subject in need thereof, whereby the prodrugs are cleaved in the colon and the PDE4 inhibitor released.