The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2023
Filed:
Nov. 20, 2018
Deutsches Krebsforschungszentrum, Heidelberg, DE;
Ruprecht-karls-universitaet Heidelberg, Heidelberg, DE;
Matthias Eder, Simonswald, DE;
Klaus Kopka, Dresden, DE;
Martin Schaefer, Neckarsteinach, DE;
Ulrike Bauder-Wuest, Schriesheim, DE;
Uwe Haberkorn, Schwetzingen, DE;
Ann-Christin Eder, Simonswald, DE;
Jens Cardinale, Vienna, AT;
Martina Benesova, Neckarsteinach, DE;
Deutsches Krebsforschungszentrum, Heidelberg, DE;
Ruprecht-Karls -Uni versitaet Heidelberg, Heidelberg, DE;
Abstract
The present invention relates to a compound of a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; xis a spacer or a chemical single bond covalently connecting (A) to the rest of the molecule; xis a spacer or a chemical single bond covalently connecting (C) to the rest of the molecule. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.