The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 02, 2023

Filed:

Sep. 17, 2020
Applicant:

Korea Institute of Science and Technology, Seoul, KR;

Inventors:

Hyoung Ja Kim, Seoul, KR;

Chang Bae Jin, Seoul, KR;

Hyun Beom Lee, Seoul, KR;

Hyun Soo Choi, Seoul, KR;

You Bin Cho, Seoul, KR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 36/73 (2006.01); A61K 9/00 (2006.01); C07H 15/24 (2006.01);
U.S. Cl.
CPC ...
A61K 36/73 (2013.01); A61K 9/0019 (2013.01); A61K 9/0056 (2013.01); A61K 9/0095 (2013.01); C07H 15/24 (2013.01); A61K 2236/333 (2013.01);
Abstract

Disclosed are aalcoholic extract and solvent fractions fractionated therefrom or novel compounds 1 and 2 purely isolated from aethyl acetate fraction that have an excellent inhibitory effect against HMG-CoA reductase activity, an excellent antioxidant effect and a remarkably excellent effect of suppressing the formation of foam cells in macrophages. Also, disclosed is a pharmaceutical composition or health food composition for treating, preventing and ameliorating vascular diseases, hypercholesterolemia, or heart diseases caused by hypercholesterolemia, or lowering blood cholesterol levels, containing, as active ingredients, thealcoholic extract and the solvent fractions or the novel compounds 1 and 2.


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