The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2023
Filed:
Sep. 25, 2019
Applicant:
Astellas Pharma Inc., Tokyo, JP;
Inventors:
Shinsuke Nakao, Tokyo, JP;
Tatsuya Kawase, Tokyo, JP;
Assignee:
Astellas Pharma Inc., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61K 38/20 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C12N 15/24 (2006.01); A61K 39/395 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61K 38/208 (2013.01); A61K 38/2046 (2013.01); A61K 39/39558 (2013.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C12N 7/00 (2013.01); A61K 2039/545 (2013.01); C12N 2710/24132 (2013.01); C12N 2710/24143 (2013.01);
Abstract
The present invention provides a combination therapy of genetically modified vaccinia virus (particularly oncolytic vaccinia virus) and another cancer therapy for use in treating cancer, and a pharmaceutical composition and a combination kit for use in the therapy. More specifically, the invention provides a therapy with vaccinia virus containing a polynucleotide encoding interleukin-7 (IL-7) and a polynucleotide encoding interleukin-12 (IL-12) in combination with an immune checkpoint inhibitor, and a pharmaceutical composition and a combination kit for use in the therapy.