The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2023
Filed:
Feb. 11, 2021
Assistance Publique—hopitaux DE Paris, Paris, FR;
Fondation Imagine—institut Des Maladies Génétiques, Paris, FR;
Université Paris Cité, Paris, FR;
Institut National DE LA Santé ET DE LA Recherche Médicale (Inserm), Paris, FR;
Isabelle André, Issy les Moulineaux, FR;
Marina Cavazzana, Paris, FR;
Kuiying Ma, Paris, FR;
John Tchen, Pantin, FR;
Tayebeh-Shabi Soheili, Paris, FR;
Ranjita Devi Moirangthem, Paris, FR;
Assistance Publique—Hopitaux de Paris, Paris, FR;
Fondation Imagine—Institut des Maladies Génétiques, Paris, FR;
Université Paris Cité, Paris, FR;
Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, FR;
Abstract
The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.