The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2023
Filed:
Oct. 06, 2021
Universiteit Antwerpen, Antwerp, BE;
Koen Augustyns, Wilrijk, BE;
Jurgen Joossens, Wilrijk, BE;
Pieter Van Der Veken, Wilrijk, BE;
Paul Cos, Wilrijk, BE;
Cedric Joossen, Wilrijk, BE;
Benedicte Yvonne De Winter, Wilrijk, BE;
Hannah Ceuleers, Wilrijk, BE;
Hanne Van Spaendonk, Wilrijk, BE;
Universiteit Antwerpen, Antwerp, BE;
Abstract
The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.