The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2023
Filed:
Nov. 27, 2019
10x Genomics, Inc., Pleasanton, CA (US);
Michael Schnall-Levin, San Francisco, CA (US);
Rajiv Bharadwaj, Pleasanton, CA (US);
Zahra Kamila Belhocine, Fremont, CA (US);
Andrew D. Price, Hayward, CA (US);
Yifeng Yin, Elk Grove, CA (US);
Vijay Kumar Sreenivasa Gopalan, Santa Clara, CA (US);
Zeljko Jovan Dzakula, San Diego, CA (US);
10X GENOMICS, INC., Pleasanton, CA (US);
Abstract
Systems and methods for inferring a status of a cell population are provided. Described techniques allow deconvolving a first clonal population comprising a first plurality of cells of a species, wherein nucleic acid sequence reads from each cell in the first plurality of cells are obtained. The nucleic acid sequence reads are mapped into bins representing portions of a reference genome, and a pattern of sequence read counts for each cell across the multiple bins is used to assign a cell to a group, thereby inferring a mitotic status of the cell. The assignment of nucleic acid sequence reads into bins is also be used for segregating cells into classes based on a status of a certain biological marker in each cell. Comparison of sequence read counts for a subset of bins across the cell classes allows evaluating effect of a compound on a cell status.