The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2023
Filed:
Dec. 27, 2021
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Shahram Misaghi, South San Francisco, CA (US);
Bradley R. Snedecor, South San Francisco, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 30/06 (2006.01); C07K 16/00 (2006.01); C12N 15/85 (2006.01); C12N 15/90 (2006.01); C40B 40/02 (2006.01);
U.S. Cl.
CPC ...
C40B 30/06 (2013.01); C07K 16/005 (2013.01); C12N 15/85 (2013.01); C12N 15/907 (2013.01); C40B 40/02 (2013.01); C07K 2317/14 (2013.01); C07K 2317/31 (2013.01);
Abstract
The presently disclosed subject matter relates to 'Randomized Configuration Targeted Integration' (also referred to herein as 'Randomized Chain Targeted Integration') (RCTI) strategies for the generation and identification of host cells capable of expressing recombinant proteins, e.g., monoclonal antibodies, as well as compositions derived from the same, e.g., bispecific antibodies, and other complex format proteins, e.g., membrane protein complexes and other difficult to express molecules.