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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11634743 B1

PDFFull Text
Date of Patent:
Apr. 25, 2023

Filed:

Jun. 19, 2017

Coupled, self-sufficient biotransformation of chenodeoxcholic acid to ursodeoxycholic acid and novel enzyme mutants applicable in said process

Applicant:

Pharmazell Gmbh, Raubling, DE;

Inventors:

Daniel Bakonyi, Cologne, DE;

Werner Hummel, Titz, DE;

Ralf Gross, Stephanskirchen, DE;

Assignee:

Pharmazell GmbH, Raubling, DE;

Attorneys:

Saul Ewing LLP

Brian R. Landry

Justin W. Crotty

Primary Examiner:

David Steadman

Int. Cl.
CPC ...
C12N 9/04 (2006.01); C12P 7/26 (2006.01); C12P 33/02 (2006.01);
U.S. Cl.
CPC ...
C12P 33/02 (2013.01); C12N 9/0006 (2013.01); C12Y 101/01159 (2013.01); C12Y 101/01201 (2013.01);
Abstract

The present invention relates to a coupled biotransformation process of converting chenodeoxycholic acid (CDCA) and related compounds to ursodeoxycholic acid (UDCA) and related compounds. It also relates to the cloning, expression, and biochemical characterization of a novel NADP-dependent 7α-hydroxysteroid dehydrogenase (7α-HSDH) from, cofactor switch mutants thereof, and their application for the oxidation of bile acids. A further aspect of the invention relates to novel NADP-dependent cofactor switch mutants of the NADP-dependent 7α-HSDH ofand their application for the oxidation of bile acids.

Find Patent Forward Citations

Bakonyi, Daniel. (2023). Coupled, self-sufficient biotransformation of chenodeoxcholic acid to ursodeoxycholic acid and novel enzyme mutants applicable in said process (U.S. Patent No. 11634743). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11634743

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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