The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11634712 B1

Date of Patent:

Apr. 25, 2023

Filed:

Aug. 25, 2020

Nucleic acid simultaneously inhibiting expression of mtor gene and stat3 gene

Applicant:

Curigin Co., Ltd., Seoul, KR;

Inventor:

Jin-Woo Choi, Seoul, KR;

Assignee:

CURIGIN CO., LTD., Seoul, KR;

Attorney:

Sughrue Mion, PLLC

Primary Examiner:

Amy H Bowman

Int. Cl.

CPC ...

C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12N 15/113 (2010.01); A61P 35/00 (2006.01); A61K 31/282 (2006.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01); A61K 33/243 (2019.01);

U.S. Cl.

CPC ...

C12N 15/113 (2013.01); A61K 31/282 (2013.01); A61K 31/713 (2013.01); A61K 31/7105 (2013.01); A61K 33/243 (2019.01); A61P 35/00 (2018.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/30 (2013.01);

Abstract

The present invention relates to a nucleic acid molecule simultaneously inhibiting the expression of mTOR gene and STAT3 gene, and an anticancer pharmaceutical composition comprising the same. More specifically, base-paired siRNA or shRNA of the present invention, designed to simultaneously inhibit the expression of cancer-related mTOR gene and STAT3 gene in order to surmount the problem that siRNA or shRNA does not achieve high therapeutic effects due to the target specificity thereof, has the effect of promoting the death of cancer cells. In addition, the nucleic acid has the effect of synergistically enhancing the apoptosis of cancer cells when used in combination with an anticancer agent, finding useful applications as an anticancer composition or anticancer aid against various carcinomas.

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