The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2023
Filed:
Jun. 03, 2019
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Jamie M. Mccabe Dunn, Cranford, NJ (US);
Nadine Kuhl, Garwood, NJ (US);
Wenyong Chen, Princeton, NJ (US);
Yang Cao, Scotch Plains, NJ (US);
Donald R. Gauthier, Jr., Westfield, NJ (US);
Alan Michael Hyde, Metuchen, NJ (US);
Susan L. Zultanski, Brooklyn, NY (US);
Jamie M. McCabe Dunn, Cranford, NJ (US);
Nadine Kuhl, Garwood, NJ (US);
Wenyong Chen, Princeton, NJ (US);
Yang Cao, Scotch Plains, NJ (US);
Donald R. Gauthier, Jr., Westfield, NJ (US);
Alan Michael Hyde, Metuchen, NJ (US);
Susan L. Zultanski, Brooklyn, NY (US);
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
The present invention provides processes for the preparation of sugammadex: (I) In one aspect, there is provided a process for the preparation of sugammadex from 8-per-deoxy-8-bromo-γ-cyclodextrin and 3-mercaptopropionic acid. In another aspect, there is provided an alternative process for the preparation of sugammadex from 8-per-deoxy-8-bromo-γ-cyclodextrin and disodium 3 -mercaptopropionate. In another aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-γ-cyclod extrin, which may be used in the production of sugammadex. In one such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-y-cyclodextrin from γ-cyclodextrin and a brominating agent. In another such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-γ-cyclodextrin comprising, inter alia, reacting γ-cyclodextrin with an electrophilic brominating agent, a deoxygenating agent, and an acid in the presence of an organic solvent.