The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2023
Filed:
Mar. 13, 2014
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Wei Yan, Sammamish, WA (US);
Martin J. Pentony, Seattle, WA (US);
Luis G. Borges, Redwood City, CA (US);
Mark L. Michaels, Encino, CA (US);
Assignee:
AMGEN INC., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/30 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); C07K 16/2803 (2013.01); C07K 16/2809 (2013.01); C07K 2317/31 (2013.01); C07K 2317/35 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/60 (2013.01); C07K 2317/626 (2013.01); C07K 2317/64 (2013.01); C07K 2317/73 (2013.01); C07K 2317/94 (2013.01);
Abstract
Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.