The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 25, 2023

Filed:

Mar. 10, 2020
Applicants:

Omrix Biopharmaceuticals Ltd., Rehovot, IL;

Ethicon, Inc., Somerville, NJ (US);

Inventors:

Erez Ilan, Kibbutz Netzer Sereni, IL;

Kfir Regev, Tel-Aviv, IL;

Dana Leitman, Tel-Aviv, IL;

Israel Nur, Moshav Timmorim, IL;

Moti Meron, Herzliah, IL;

John Goodman, Ann Arbor, MI (US);

Assignees:

Omrix Biopharmaceuticals Ltd., Rehovot, IL;

Ethicon, Inc., Somerville, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/75 (2006.01); A61M 5/19 (2006.01); A61M 5/28 (2006.01); B01F 23/50 (2022.01); B01F 25/451 (2022.01); B01F 33/25 (2022.01); B01F 33/501 (2022.01); B01F 35/71 (2022.01);
U.S. Cl.
CPC ...
C07K 14/75 (2013.01); A61M 5/284 (2013.01); B01F 23/50 (2022.01); B01F 25/4512 (2022.01); B01F 33/251 (2022.01); B01F 33/50112 (2022.01); B01F 35/718 (2022.01); B01F 35/7163 (2022.01); A61M 5/19 (2013.01);
Abstract

Provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. The methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. Aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. The devices are suitable for use in the disclosed method.


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