The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 25, 2023

Filed:

Jan. 29, 2020
Applicant:

Shire-nps Pharmaceuticals, Inc., Lexington, MA (US);

Inventors:

Clark Pan, Sudbury, MA (US);

Angela Norton, Reading, MA (US);

Kevin Holmes, Belmont, MA (US);

David Bruce Lloyd, Leland, NC (US);

Bryan James Goodwin, Lexington, MA (US);

Rongxin Shi, Waltham, MA (US);

Sujit Jain, Lexington, MA (US);

Chuan Shen, West Roxbury, MA (US);

Assignee:

SHIRE-NPS PHARMACEUTICALS, INC., Lexington, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/635 (2006.01); A61K 9/00 (2006.01); A61P 5/18 (2006.01); C07K 1/16 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/635 (2013.01); A61K 9/0014 (2013.01); A61P 5/18 (2018.01); C07K 1/165 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract

The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.


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