The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2023
Filed:
Aug. 17, 2018
Applicant:
The U.s.a., As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventor:
Claire Y. Kinney, Fort Collins, CO (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C07K 14/18 (2006.01); C12N 7/00 (2006.01); C12Q 1/70 (2006.01);
U.S. Cl.
CPC ...
C07K 14/1825 (2013.01); C12N 7/00 (2013.01); C12Q 1/701 (2013.01); C12N 2770/24122 (2013.01); C12N 2770/24141 (2013.01);
Abstract
Chimeric flaviviruses engineered to contain a reporter gene and chimeric nucleic acid molecules encoding the chimeric flaviviruses are described. The chimeric flaviviruses further include genomic non-coding regions, non-structural proteins, and at least a portion of a capsid (C) protein from West Nile virus (WNV), and premembrane (prM) and envelope (E) proteins from dengue virus (DENV). Diagnostic assays that utilize chimeric West Nile/dengue viruses are further described.